个人简介：

赵立华，女，博士，副研究员，硕士生导师。云南省兴滇英才“青年人才”。功能基因组学与基因资源利用创新团队组长。主要从事抗病毒、真菌、细菌等天然产物筛选及抗病机理方面的研究。从入侵生物肿柄菊、三裂叶蟛蜞菊以及中药材岩乌头、粉防己等植物提取物中筛选到具有抗病毒潜力的萜类、黄酮类等化合物10余个，通过将生物信息学、蛋白互作等分子生物学、超微结构观察等技术手段相结合解析其抗病机理。对云南低纬高原重要经济林木、中药材、蔬菜、花卉等经济作物的病毒病害进行监测预警、同时在病毒致病机理、绿色防控综合体系构建等方面做出了重要贡献。主持国家自然科学基金2项、云南省自然科学基金重点项目1项，面上项目1项，云南省“兴滇人才”项目1项，作为项目骨干参与国家基金重大项目、重大研发等项目10余项。以第一作者（含共同一作）或通讯作者在Plant, Cell & Environment、Agriculrure and Food Chemistry、PBP、Journal of Plant Pathology、Plant Diseases、植物病理学报等杂志上发表文章30余篇，其中 SCI 论文24篇，授权专利6件。指导本科生获全国大学生生命科学竞赛国家级三等奖等奖项。

部分主持项目：

[1] 国家自然科学基金地区基金，圆叶肿柄菊素A调控转录因子MYB80抑制TSWV系统侵染的分子机制，在研，主持。

[2] 国家自然科学基金地区基金，圆叶肿柄菊素A诱导茉莉酸通路抑制TSWV侵染的分子机制，结题，主持。

[3] 云南省人社厅兴滇人才计划，圆叶肿柄菊素A抑制TSWV系统侵染的分子机制，在研，主持。

[4] 云南省科技厅科技计划重点项目，圆叶肿柄菊素A调控茉莉酸通路COI1蛋白抑制TSWV系统侵染的分子机制，在研，主持。[5] 贵州医科大学省部共建药用植物功效与利用国家重点实验室开放项目，天然喹诺里西啶类生物碱抗番茄斑萎病毒作用机制研究，在研，主持。

[6] 云南省科技厅科技计划面上项目，圆叶肿柄菊素A抑制番茄斑萎病毒复制、装配机制，结题，主持。

部分代表性论文：

[1] Lihua Zhao，Yanliang Wang，Runshuang Qiu，Si Chen，Sijie He，Yu Li，Tiantian Wang，Jing Li，Zhongkai Zhang. The TSWV Movement Protein NSm Coopts Host Immunity Proteins NtPOX1 and NtPR‐4A to Induce Pathological Vesicles for Viral Replication. Plant, Cell & Environment. (一区Top). 2026. 1-18.

[2] Runshuang Qiu, Jing Li, Si Chen, Lizhen Zhang, Xingli Bai, Yuxin Zhang, Lu Jia, Lihua Zhao. Synergistic Interaction Between Southern Tomato Virus and Tomato Spotted Wilt Virus During Tomato Infection. Agriculture. 2026. 16, 1625.

[3] Lihua Zhao, Ping Yu, Tong Zhang, Xue Zheng, Runshuang Qiu, Xiaoqin Duan, Zhanxing Hu, Jing Li. Berberine from Corydalis saxicola Bunting reveals anti-tomato spotted wilt orthotospovirus activity with a novel mechanism. Plant Physiology and Biochemistry 227 (2025) 110119.

[4] Zhanxing Hu, Ji Zhang, Tong Zhang, Caiyan Tian, Qiao An, Ping Yi, Chunmao Yuan, Zhongkai Zhang, Lihua Zhao*, Xiaojiang Hao*. Aloperine-type alkaloids with antiviral and antifungal activities from the seeds of Sophora alopecuroides L. J. Agric. Food Chem. 2024.72: 8225-8236.

[5] Tong Zhang, Caiyan Tian, Ji Zhang, Qiao An, Ping Yi, Chunmao Yuan, Zhongkai Zhang, Lihua Zhao*, Xiaojiang Hao*, Zhanxing Hu*. Quinolizidine Alkaloids and isoflavones from the herb of Thermopsis lupinoides and their antiviral, antifungal, and insecticidal activities. J.Agric. Food. Chem. 2024. 72(9): 5047-5061.

[6] Runshuang Qiu, Lizhen Zhang, Yanan Du, Yumeng Du, Xue Zheng, Zhongkai Zhang*, Lihua Zhao*. First report of tobacco mosaic virus infecting Anisomeles indica (L.) Kuntze in China. Plant Disease. 2023. 107: 1954.

[7] Yumeng Du, Xuwang Yang, Runshuang Qiu, Shuiying Zhang, Lihua Zhao*, Zhongkai Zhang*. First report of tomato spotted wilt virus (TSWV) infection on Polygonatum kingianum in China. Journal of Plant Pathology. 2023. 105: 1197.

[8] Peng Zhang, Ji Zhang, Qiao An, Juan Wang, Ping Yi, Chunmao Yuan, Zhongkai Zhang, Lihua Zhao*, Zhanxing Hu*, Xiaojiang Hao*. Matrine-type alkaloids with anti-tomato spotted wilt virus activity from the root of Sophora tonkinensis Gagnep. J. Agric. Food Chem. 2023. 71(10): 4394-4407.

[9] Lihua Zhao, Lizhen Zhang, Zhonghui Hu, Bowen Li, Xue Zheng, Runshuang Qiu, Yue Chen, Jing Li, Jiahong Dong, Zhongkai Zhang. Tomato zonate spot virus induced hypersensitive resistance via an auxin-related pathway in pepper. Gene. 2022. 823: 146320.

[10] Zhanxing Hu#, Peng Zhang#, Jibin Zou#, Qiao An, Ping Yi, Chunmao Yuan, Zhongkai Zhang*, Lihua Zhao*, Xiaojiang Hao*. Quinolizidine Alkaloids with antitomato spotted wilt virus and insecticidal activities from the seeds of Thermopsis lanceolata R. Br. J. Agric. Food Chem. 2022. 70: 9214−9226.

[11] Lihua Zhao, Zhonghui Hu, Shunlin Li, Lizhen Zhang, Ping Yu, Jie Zhang, Xue Zheng, Siddiqur Rahman, Zhongkai Zhang*. Tagitinin A from Tithonia diversifolia provides resistance to tomato spotted wilt orthotospovirus by inducing systemic resistance. Pesticide Biochemistry and Physiology. 2020. 169: 104654.

[12] Jibin Zou#, Lihua Zhao#, Ping Yi, Qiao An, Longxiang He, Yanan Li, Huayong Lou, Chunmao Yuan, Wei Gu, Liejun Huang, Zhanxing Hu*, Xiaojiang Hao*. Quinolizidine alkaloids with antiviral and insecticidal activities from the seeds of Sophora tonkinensis Gagnep. J. Agric. Food Chem 2020. 68: 15015-15026.